A complex of metabolic signs may be outlined for optimal physiologic entering into hibernation. Such sings are: rise of serotoninergic activity in the central nervous system and growth of serotonin concentration in blood, higher histamin level in the blood plasma. Unfavourable signs are: low level of serotonin in brain and in blood, cateholamin depot exhaustion in suprarenals and myocard, reduced histamin concentration in plasma and high level of adrenalin circulating in blood.
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